ABSTRACT
Background: Sodium iodide symporter (NIS), a transporter of iodine is essential for thyroid hormone biosynthesis. It also plays a role in the radioiodine treatment of thyroid cancers. NIS mediated radioiodine transport to breast cancers is under active investigation due to its potential therapeutic utility. Cellular localization and quantification using immunohistochemistry may provide clues for its utility in management of carcinoma breast. Materials and Methods: Human NIS (hNIS) expression was therefore assessed by utilizing a rabbit polyclonal antibody raised against a cloned hNIS in different grades of infiltrating duct carcinoma of breast and its metastatic deposits namely in lymph nodes, bone marrow, and endometrium. Further, hNIS expression was compared with prognostic markers namely estrogen receptor (ER) and progesterone receptor (PR). Results: hNIS was positive in 90.6% cases (29/32) and Scarff-Bloom-Richardson grading was done in 25 cases and 23 cases were NIS positive. Among nongraded cases, 2/2 cases of carcinoma in-situ were positive and 4/5 were positive in cases having post therapy residual tumor status. The strong positivity for hNIS was seen irrespective of ER or PR status and of grade of breast carcinoma and correlated well with western blot analysis. In all the three metastatic sites, NIS was positive in the tumor. Conclusion: These findings indicate the utility of immnohistochemistry for NIS as a new potential prognostic marker and may provide guidance for possible radio iodine therapy in breast cancer patients.
Subject(s)
Adult , Aged , Animals , Bone Marrow/pathology , Bone Neoplasms/pathology , Bone Neoplasms/secondary , Breast Neoplasms/pathology , Breast Neoplasms/secondary , Carcinoma/pathology , Endometrium/pathology , Female , Humans , Immunohistochemistry , Lymph Nodes/pathology , Microscopy , Middle Aged , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Symporters/analysis , Uterine Neoplasms/pathology , Uterine Neoplasms/secondaryABSTRACT
Ovarian teratomas are known for their ability to form a wide variety of tissues. One unusual example of this potential is the strumal carcinoid in which the thyroid tissue is found in intimate association with carcinoid tumor. Although considered as a malignant transformation of struma ovarii, it is almost always benign. We report a rare case of strumal carcionid in a 44 year old lady who had metastasis in the contralateral ovary, myometrium and lungs.
Subject(s)
Adult , Carcinoid Tumor/pathology , Female , Humans , Lung Neoplasms/secondary , Myometrium/pathology , Ovarian Neoplasms/pathology , Struma Ovarii/pathology , Uterine Neoplasms/secondaryABSTRACT
A frequência de metástases de carcinoma mamário no útero varia, segundo a literatura, de 2 porcento a 5 porcento dos casos. Os autores apresentam um caso de adenocarcinoma de mama com metástase em paracérvix e miométrio. A paciente submetida a histerectomia total e ooforectomia bilateral. A discussäo sobre o diagnóstico e tratamento é baseada na revisäo da literatura.
Subject(s)
Adenocarcinoma/diagnosis , Breast Neoplasms , Uterine Neoplasms/secondary , Neoplasm MetastasisABSTRACT
Se evalúa la utilidad de la biopsia contemporánea para determinar la profundidad de invasión miometrial en 30 pacientes con diagnóstico de cáncer endometrial en el raspado endometrial previo. Se utilizó la técnica de biopsia por congelación con dos cortes en el punto de máxima lesión macroscópica intracavitaria. Los resultados de la biopsia contemporánea se comparan con el estudio diferido. En 29 casos, el estudio contemporáneo diagnosticó correctamente la profundidad de invasión miometrial. La concordancia fue de 96,6%. Se concluye que este método es altamente exacto y de bajo costo para determinar la profundidad de invasión miometrial en el intraoperatorio. Esta metodología ayuda al cirujano a decidir la extensión de la cirugía de etapificación especialmente la realización de linfadenectomía
Subject(s)
Humans , Female , Biopsy , Diagnostic Techniques, Surgical , Endometrial Neoplasms/pathology , Endometrial Neoplasms/surgery , Neoplasm Invasiveness/pathology , Uterine Neoplasms/secondary , Uterine Neoplasms/surgeryABSTRACT
Um raro caso de melanoma metastatico em útero e ovário, de paciente com 47 anos, é aqui relatado. Somente após ter conhecimento do laudo histopatológico que a paciente referiu a exerese de lesäo enegrecida de seu dorso, 16 meses antes da pan-histerectomia, sendo desprezado o material naquela ocasiäo. O óbito ocorreu 4 meses após a cirurgia ginecológica, por metástases cerebrais